In April 2025, scientists, medical practitioners, communication professionals, and policy advocates from eight countries met to discuss progress in these experiments and their outreach to policymakers in the EU and beyond.
Novel test methods for reproductive toxicity
From models with reproductive and brain tissues to whole organism models with zebrafish, quails and C.elegans worms, the MERLON team is testing the limits of new approach methodologies.
Our researchers started by studying the effects of di(2-ethylhexyl)phthalate (DEHP), a known endocrine disruptor commonly used in plastics to make them more flexible. They completed initial studies examining how DEHP affects reproductive and brain development in rodents, with a focus on less studied health impacts. This research will help guide future tests using human cells.
These findings provide important data on sexual development and hormone disruption, revealing both the strengths of current test methods and potential limitations that should be addressed in future research.
Taking the conversation to policymakers
MERLON researchers are advocating for policymakers to take action to protect people's health. After five years, the project aims to create a comprehensive roadmap for advancing EDC identification, potentially transforming chemical safety assessment throughout Europe and beyond.
